A15 15..15

نویسنده

  • Kimberlie Dean
چکیده

Several papers in the BJPsych this month present findings that challenge accepted notions in psychiatry, and one paper focuses specifically on the extent to which the findings of highly cited papers are subsequently replicated. Tajika et al (pp. 357–362) identified highly cited studies claiming evidence of effective treatments reported in a range of high-impact general medical and psychiatric journals. Following the progress of attempts at replication in the literature over 10 years, the authors found almost half had not been subject to any attempt at replication (40 of 83), 16 were contradicted and 11 were found to have substantially smaller effects. The authors advise readers to exercise caution when interpreting the significance of studies reporting large treatment effects on the basis of small study samples, even if the studies are published in high-impact journals and are highly cited. Challenging the notion that stigma is the explanation for the reluctance of military personnel to seek treatment for mental ill health, Adler et al (pp. 346–350) found evidence to support a broadening of the conceptualisation of barriers to and facilitators of mental healthcare and, in particular, found an important preference for self-management among surveyed US soldiers. In the field of interventions for mental health vocational rehabilitation, the effectiveness of individual placement and support (IPS) is well accepted. However, its implementation has been limited by the requirements for time-unlimited support and fixed case-loads. Burns et al (pp. 351–356) challenge the essential nature of these requirements and find that IPS-LITE (time-limited) is equally effective to IPS and, the authors argue, may be more cost-effective. Also challenging current notions are arguments made in favour of applying a developmental perspective to psychiatric classification in an editorial by Hall & Owen (pp. 281–282), while Castle and Singh (pp. 288–292) debate the current notion that separate early intervention in psychosis is still the best option.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

cw laser annealing of Nb3AI and Nb3Si

cw laser annealing has been applied to synthesize the metastable A 15 superconductors, Nb3AI and Nb3Si. Qualitative agreement with the equilibrium phase diagrams have been obtained for the Nb-AI system. Laser annealing permits the high-temperature A15 phase to be fast quenched to room temperature without decomposition. Subsequent use of multiple low-temperature laser scans raises the supercondu...

متن کامل

Information Entropy of Influenza A Segment 7

Information entropy (H) is a measure of uncertainty at each position within in a sequence of nucleotides. H was used to characterize a set of influenza A segment 7 nucleotide sequences. Nucleotide locations of high entropy were identified near the 5’ start of all of the sequences and the sequences were assigned to subsets according to synonymous nucleotide variants at those positions: either ur...

متن کامل

Lysine Acetylation Controls Local Protein Conformation by Influencing Proline Isomerization

Gene transcription responds to stress and metabolic signals to optimize growth and survival. Histone H3 (H3) lysine 4 trimethylation (K4me3) facilitates state changes, but how levels are coordinated with the environment is unclear. Here, we show that isomerization of H3 at the alanine 15-proline 16 (A15-P16) peptide bond is influenced by lysine 14 (K14) and controls gene-specific K4me3 by balan...

متن کامل

Probing the applicability of autotransporter based surface display with the EstA autotransporter of Pseudomonas stutzeri A15

BACKGROUND Autotransporters represent a widespread family of secreted proteins in Gram-negative bacteria. Their seemingly easy secretion mechanism and modular structure make them interesting candidates for cell surface display of heterologous proteins. The most widely applied host organism for this purpose is Escherichia coli. Pseudomonas stutzeri A15 is an interesting candidate host for enviro...

متن کامل

Extinctions at 7μm and 15μm from the ISOGAL survey

The extinction laws at 7μm and 15μm are derived for more than 120 sightlines in the inner Galactic plane based on the ISOGAL survey data and the near-infrared data from DENIS and 2MASS. The tracers are the ISOGAL point sources with [7]-[15]<0.4 which are RGB tip stars or early AGB stars with moderate mass loss. They have well-defined intrinsic color indices (J-Ks)0, (Ks-[7])0 and (Ks-[15])0. By...

متن کامل

Determining the preference , in vitro digestibility , in situ disappearance , and grower period performance of steers fed a novel algae meal derived from heterotrophic microalgae 1

A series of 3 experiments were conducted to determine the in vitro and in situ disappearance, preference, and performance of steers consuming increasing concentrations of a novel feedstuff called algae meal (ALG). In Exp. 1 and 2, 3 ruminally cannulated steers (998 ± 103 kg BW) and 4 treatments were utilized: a dry-rolled corn-based diet (CON), or 15% ALG (A15), 30% ALG (A30), or 45% ALG (A45) ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010